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Effects of acupuncture on rates of pregnancy and live birth among women undergoing in vitro fertilisation: systematic review and meta-analysis BMJ Online First

 

Preliminary results published on bmj.com today suggest that acupuncture given with embryo transfer can improve rates of pregnancy and live birth among women undergoing in vitro fertilisation.

 

Some 10 to 15% of couples have difficulty conceiving at some point in their reproductive lives and seek specialist fertility treatment. A commonly used option is in vitro fertilisation, which involves retrieving a woman’s egg, fertilising the egg in the laboratory, and then transferring the embryo back into the woman’s womb.

In 2000, approximately 200,000 babies worldwide were conceived through in vitro fertilisation.

 

Because each cycle is expensive, lengthy, and stressful, new drugs and technologies have been developed to improve success rates, but progress has been limited.

However, acupuncture has been used in China for centuries to regulate the female reproductive system. So researchers at the University of Maryland School of Medicine and the VU University Amsterdam set out to determine whether acupuncture given with embryo transfer improves the rates of pregnancy and live birth among women undergoing in vitro fertilisation.

They reviewed seven trials involving 1,366 women undergoing in vitro fertilisation. The trials compared acupuncture, administered within one day of the embryo transfer procedure, with sham acupuncture or no additional treatment.

The overall quality of the trials was good and included a broad selection of women at various ages and with different causes and durations of infertility.

Complementing the embryo transfer process with acupuncture increased the odds of pregnancy by 65% compared to sham acupuncture or no additional treatment. In absolute terms, this means that 10 women would need to be treated with acupuncture to bring about one additional pregnancy.

In trials where the baseline pregnancy rates were already high, the benefit of acupuncture was smaller and non-significant.

Although still somewhat preliminary, this review suggests that acupuncture given with embryo transfer can improve rates of pregnancy and live birth among women undergoing in vitro fertilisation, say the authors.

In vitro fertilisation is an expensive procedure, costing an average of $12,400 per cycle in the United States, they add. So, even if the increased likelihood of success with acupuncture was small, it may still be cost-effective.

They call for further studies to confirm these preliminary findings and to investigate the relation between baseline rate of pregnancy and the effectiveness of additional acupuncture.

Contact:
Eric Manheimer, Research Associate, Center for Integrative Medicine, University of Maryland School of Medicine, Baltimore, USA
Tel: +1 410 448 6890; Mobile: +1 410 790 6021

 
Source: http://www.bmj.com/

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