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The dangers of double dipping

DOI: 10.1038/nn.2303

Analyses of data from functional magnetic resonance imaging (fMRI) and studies tracking electrical activity in the brain can generate misleading results, suggests an article online this week in Nature Neuroscience.

 

Techniques such as fMRI, which provides images of the brain, and electrophysiology, which record electrical activity from many neurons at once, generate a large amount of data. Some of this data is intrinsically ‘noisy’, being accompanied by other background activity, like listening to a radio station with poor signal quality. In order to enhance the signal of interest, the raw data is substantially analyzed, often using complex transformations.

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