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Level of cellular stress determines longevity of retinal cells

Stress can be adaptive.

 

It can make you sharper, help you focus and it can even improve your performance. But too much of it can tax cells to the point where they can no longer cope and slowly self-destruct. Scientists at Rockefeller University now show that when the protein-making factory of the cell is exposed to moderate stress, neurons in the fruit fly retina and other cells not only resist death but also shore up their defenses against damaging free radicals and ultraviolet radiation.

The finding sheds light on the molecular mechanism by which cells compute their fate, and may point to therapeutic targets that protect against or delay the onset of neurodegeneration.

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